临沂市部分人群麻疹抗体水平及麻疹疫苗强化免疫血清学效果监测

Surveillance on measles antibody level in healthy population and serological effect of intensive immunization with measles vaccine

目的 了解临沂市麻疹疫苗强化免疫的效果和人群麻疹抗体水平。方法 随机抽取 2个县区 15 3 4名 0～ 3 9岁健康人 ,应用酶联免疫吸附试验检测麻疹IgG抗体。结果 15 3 4人中抗体阳性 1190人 ,阳性率 77 5 7% ,几何平均滴度 (GMT) 1∶783。 1～ 12岁儿童抗体阳性率最高 (85 71%～ 98.44 % ) ,GMT则从 6岁开始下降至中低等水平 ,抗体阳性率有随年龄增长而下降的趋势。观察麻疹疫苗初种 8～ 12月龄儿童 188人 ,免疫成功率为 96 81% ;麻疹疫苗复种 5～ 7岁儿童 186人 ,免疫成功率 61 2 9% ;免疫后抗体GMT初、复种疫苗分别比免疫前提高 2 8 4倍和 3 1倍。结论 大年龄儿童及成人的麻疹抗体水平仅达到中低水平 ;不论是初种或复种 。

Objective To study the effect of intensive immunization with measles vaccine and the measles antibody level in healthy population. [Methods] ELISA was adopted to detect the measles IgG-antibody of the randomly selected 1 534 healthy people between the age of 0 to 39 from 2 counties. [Results] The antibody positive rate was 77.57% (1 190/1 534); GMT was 1:783. The antibody positive rate was the highest among children between the age of 1 to 12 (85.71%～98.44%). GMT began to descend to middle and low level from 6 years old. The antibody positive rate showed a decreasing tendency along with the increase of age. The success rate of the first vaccination on 188 children aged from 8～12 months was 96.81%; the success rate of revaccination on 186 children aged from 5～7 years old was 61.29%; The GMT after the first and second vaccination increased by 28.4 and 3.1 times respectively. [Conclusion] The measles antibody level of older children and adults can only reach the middle and low level. Whether in the first vaccination or revaccination, those whose antibody was in middle and low level may have a significantly higher success rate than those with high level of antibody.