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一种新发现的肌特异基因表达调节因子:心肌素 被引量：2

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摘要 心肌素是一种新发现的特异性调节心肌和平滑肌基因表达的蛋白因子 ,与血清效应因子(SRF)一起构成肌细胞分化分子开关的组成成分。心肌素在胚胎及成年心肌和平滑肌细胞中均进行表达 ,是这两类细胞基因特异性表达及分化所必需的转录激活因子。
作者 温进坤 韩梅
机构地区 河北医科大学基础医学研究所
出处 《生理科学进展》 CAS CSCD 北大核心 2004年第3期229-232,共4页 Progress in Physiological Sciences
基金 国家自然科学基金 (90 2 0 80 14 ) 河北省自然科学基金(30 345 5 )资助课题
关键词 心肌素 心肌细胞 平滑肌细胞 基因表达 分子机制 转录激活因子
分类号 Q756 [生物学—分子生物学] Q445 [生物学—生理学]
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参考文献10

  • 1Wang DZ, Chang PS, Wang Z, et al. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell, 2001, 105: 851-862.
  • 2Wang Z, Wang DZ, Pipes GCT, et al. Myocardin is a master regulator of smooth muscle gene expression. Proc Natl Acad SCi USA, 2003, 100: 7129-7134.
  • 3Wang DZ, Li S, Hockemeyer D, et al. Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci USA, 2002, 99:14855-14860.
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  • 5Li S, Wang DZ, Wang Z, et al. The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci USA, 2003, 100: 9366-9370.
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  • 10Nishida W, Nakamura M, Mori S, et al. A triad of serum response factor and the GATA and NK families governs the transcription of smooth and cardiac muscle genes. J Biol Chem, 2002, 277:7308-7317.

同被引文献37

  • 1黄海怡,黄佐,胡国梁,侯健.骨髓单个核细胞移植对慢性心力衰竭大鼠心肌修复的远期效果[J].中国动脉硬化杂志,2005,13(4):451-455. 被引量：2
  • 2陈小明,吴可贵.雷洛昔芬对心血管的保护作用[J].中国药房,2006,17(17):1346-1348. 被引量：5
  • 3Han CI, Campbell GR, Campbell JH. Circulating bone marrow cells can contribute to neointimal formation. J Vasc Res, 2001,38 (2) :113-119.
  • 4Hillebrands JL, Klatter FA, van den Hurk BM, et al. Origin of neointimal endothelium and alpha-actin-positive smooth muscle cells in transplant arteriosclerosis. J Clin Invest, 2001, 107 ( 11 ) : 1411-1422.
  • 5Simper D, Stalboerger PG, Panetta C J, et al. Smooth muscle progenitor ceils in human blood. Circulation, 2002,106 ( 10 ) : 1199-1204.
  • 6Bochaton-Piallat ML, Clowes AW, Clowes MM, et al. Cultured arterial smooth muscle cells maintain distinct phenotypes when implanted into carotid artery. Arterioscler Thromb Vasc Biol, 2001,21 (6) :949-954.
  • 7Owens GK. Regulation of differentiation of vascular smooth muscle cells, physiol Rev, 1995,75 ( 3 ) :487-517.
  • 8Zhou J, Herring BP. Mechanisms responsible for the promoterspecific effects of myocardin. J Biol Chem, 2005, 280 ( 11 ) : 10861-10869.
  • 9Hegner B, Weber M, Dragun D, et al. Differential regulation of smooth muscle markers in human bone marrow-derived mesenchymal stem ceils. J Hypertens, 2005,23 (6) : 1191-1202.
  • 10Solway J, Seltzer J, Samaha FF, et al. Structure and expression of a smooth muscle cell-specific gene, SM22 alpha. J Biol Chem, 1995, 270 ( 22 ) : 13460-13469.

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生理科学进展
2004年 第3期

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