胆源性感染性休克兔血栓素、前列环素与血小板聚集率的变化

Studies on Changes of Thromboxane A_2,Prostacyclin and Platelet Aggregation during Biliogenic Infectious Shock in Rabbits

动态观察胆总管急性完全性梗阻并感染、继发休克兔的血浆血栓素(TXA_2)和前列环素(PGI_2)的稳定代谢产物 TXB_2和6-keto-PGF_(1α)含量及血小板聚集率的变化。结果,血浆 TXB_2呈进行性升高,20h 后(休克时)呈下降趋势,血浆6-keto-PGF_(1α)6h 升高,随后回降;血小板聚集率呈进行性下降。提示血栓素和前列环素、血小板聚集率的变化在重症急性胆管炎、胆源性感染性休克发病过程中起重要病理生理作用,与病情和预后转归有重要联系。

The dynamic changes of plasma thromboxane B_2(TXB_2)and 6-Keto-PGF_(1α)which are the stable metabolits of thromboxane A_2 and prostacyclin respectively,and platelet aggregation were observed in rabbit models of common duct acute complete obstruction and septic secondary infectious shock.The re- sult showed that the plasma levels of TXB_2 was progressively increased,but decreased in 20 hours. There was an increase in plasma levels of 6-Keto-PGF_(1α)in 6 hours only,and then a decrease occurred. Simultaneously,we found the platelet aggregation was progressively reduced.These results reveal that there are the changes of thromboxane,prostacyclin and platelet aggregation which play important patho- physiological role in acute cholangitis severe type(ACST)and biliogenic infectious shock,and which are closely related to the severity of disease and prognosis.