胆源性感染性休克兔血脂质过氧化物和抗氧化物的变化

The Changes of Blood Lipid Peroxides and Antioxidatants during Biliogenic Septic Shock in Rabbits

检测胆源性感染性休克兔模型血中脂质过氧化物(LPO)和抗氧化物维生素 E(VE),超氧化物岐化酶(SOD)及谷胱甘肽过氧化物酶(GSH-PX)含量,测定主要脏器功能指标和肝脏组织学变化。发现随休克的发生发展和肝脏病理改变的加重,LPO 上升,VE,SOD,GSH-PX 不同程度下降(P<0.05),与脏器损害明显相关(P 均<0.01)。证实脂质过氧化反应增强和抗氧化作用减弱在本模型发病过程中起重要作用。提示 LPO 及 VE,SOD,GSH-PX 的动态变化能准确反映病情。

The contents of lipid peroxides(LPO)and antioxidatants including vitamin E(VE),superoxide dis- mutase(SOD)and glutathione peroxidase(GSH-PX)in the blood from the rabbit models of biliogenic shock were measured.Simultaneously,some of the functional indexes of the main organs and histologic change in the liver in the rabbits were also observed.The results revealed that the LPO level in blood increased progressively,and the VE content,the SOD and GSH-PX activities decrcased gradually with the appearance and advance of septic shock,and with the exacerbation of pathologic changes in the liver,there were strikingly linear correlations with the changes of the functional index of main organs. It is suggested that increased lipid peroxidation and decreased antioxidative effect played an important role in biliogenic septic shock,and that the measures of LPO and the antioxidatants may determine the severity of the disease.