肝硬化联合检测总胆汁酸、透明质酸的意义

Application of Total Bile Acids and Hyaluronic Acid Chromatography in the Diagnoses of cirrhosis

目的:探索血清总胆汁酸(TBA)及透明质酸(HA)与肝硬化的关系。方法:本文检测了96例肝硬化及28例正常人的血清、腹水中的总胆汁酸(TBA)及透明质酸(HA)浓度。结果:各类肝硬化血清及腹水的总胆汁酸及透明质酸浓度均明显高于正常对照组(P<0.01)。且不同类型的肝硬化之间也有差异。结论:总胆汁酸是一种较灵敏的肝功能指标,尤其是在肝功能常规指标改变不明显时,对肝硬化的诊断有一定的价值。透明质酸能够较好地反映肝纤维增生情况,是一个良好的肝纤维化血清学诊断指标。也是反映肝硬化程度及预后的客观指标。

(AIM) In oder to explore the specificity of serum total bile acids (TBA) and Hyaluronic acid (HA) chromatogiophy in the diagnoses of different kinds of Cirrhosis.[METHOD] Serum TBA and HA were measured with radioimmunoassay in carefully collected plasma samples from 96 patients with cirrho- sis and 28 healthy controls subjects.[RESULT] TBA and HA in patients with cirrhosis were significantly high- er than healthy controls (p<0.01) in serum and ascites.[CONCLUSION]:①Serum TBA are guide index for liver function.②The raised of serum HA is a major index of hepatic fibrosis.