直肠癌切除术后动脉联合化疗对预防复发和转移的价值

The preventive effect of chemotherapy via superior mesentery artery,internal iliac artery and propria hepartic artery on recurrence and metastasis in rectal cancer after redical resectioncn

目的观察肠系膜上动脉、髂内动脉及肝固有动脉联合化疗对直肠癌根治性切除术后患者肿瘤复发和转移的预防效果方法随机选取103例直肠癌根治性切除术后患者分为两组,治疗组56例,以肠系膜上脉、髂内动脉及肝固有动脉为靶血管,采用介入导管技术分别注入化疗药物,药物为5-氟尿嘧啶+丝裂霉素 C+顺铂。对照组47例,术后采用全身静脉化疗,用药同治疗组。治疗后每组均随访5年,观察术后1-5年内肿瘤复发和转移的部位及数量。结果治疗组5年内共复发和转移18例,复发和转移率32.1％,对照组复发和转移共22例,复发和转移率47.0％,两组差异显著(p<0.01)。结论肠系膜上动脉、髂内动脉及肝固有动脉联合化疗对直肠癌根治性切除术后患者肿瘤复发和转移有预防作用。

To evaluate the preventive effect of chemotherapy via superior mesentery artery,internal iliac artery and propria hepartic artery on recurrence and metastasis in rectal cancer after redical resectiocn.Method One hundred and three cases were divided into two groups.Fifty-six cases of rectal cancer after redical resection were treated by chemo- threapy via superior mesentery artery,internal iliac artery and propria hepartic artery with 5-Fu,MMC and DDP.Forty- seven cases in control group were treated with the same drugs via vein.The rate of recurrence and metastasis were noticed in five years.Result The rate of recurrence and metastasis in treated group was 32.1% (18/56) respectively,while the rate for the control group was 47.0% (22/47).The rate of recurrence and metastasis was statistically superior to that in control group (p<0.01).Conclution The preventive effect of chemotherapy via superior mesentery artery,internal iliac artery and propria hepartic on recurrence and metastasis in rectal cancer after redical resectiocn was confirmed.