联合羟基喜树碱治疗晚期恶性肿瘤的临床观察及护理

Ciinical investigation and nursing of a combination of chemotherapy with HCPT in the treatment of patients with advanced malignant neoplasms

目的探讨联合羟基喜树碱治疗晚期恶性肿瘤的疗效及护理。方法常规化疗方案治疗后,再在原化疗方案基础上加用羟基喜树碱(10mg,Ⅳ,d1～10)治疗晚期恶性肿瘤患者。结果28例晚期恶性肿瘤中,常规化疗方案组,显效5例(17.9％);同一病人经过常规化疗方案治疗2～4疗程后,在原化疗方案基础上加用羟基喜树碱继续治疗2～5疗程,显效 CR9例(32.O％);化疗副作用:常规化疗组中,恶心呕吐13例:Ⅰ度7例,Ⅱ度5例,Ⅲ度1例。白细胞减少7例:Ⅰ度2例,Ⅱ度3例,Ⅲ度1例,Ⅳ度1例。脱发12例:Ⅰ度5例,Ⅱ度5例,Ⅲ度2例。羟基喜树碱组中,恶心呕吐18例:Ⅰ度10例,Ⅱ度7例,Ⅲ度1例;白细胞减少8例:Ⅰ度2例,Ⅱ度3例,Ⅲ度1例,Ⅳ度2例;脱发13例:Ⅰ度2例,Ⅱ度8例,Ⅲ度3例;腹泻2例;皮疹1例。二组患者均无肝肾功能损害及心电图异常。结论联合羟基喜树碱可以进一步提高晚期恶性肿瘤的疗效,主要毒副作用有所增加,但是可以接受的。

To evaluate the therapeutic effect and adverse sides of a combination of Hydroxycamptothecine (HCPY)with chemotherapy in the treatment of patients with advanced malignant neoplasms.Methods All the patients were treated for a 2～4 coures of treatment with routine chemotherapeutic plans following the treatment of the same che- motherapeutic plan plus HCPT 10mg iv for ten days.Results Twenty eight subjectives with various advanced maliganant neoplasms(Ⅳ stages) including 23 males and 5 females with a range of age from 30 to 72 years old were investigated.The patients enrolled in the present paper consisted of 10 cases with nonsmall cell lung cancer(NSCLC),9 cases with colorec- tal cancer,2 cases with gastric cancers,2 cases with esophageal cancers,3 cases with nasopharyngeal cancers,1 cases with pancreatic cancer and 1 cases with urethral cancers.Effective rates(CR+PR) were obtained in 17.9% of routine chemo- therapeutic schemes while effective rotes from combination with HCPT were increased to 32.0%.The main adverse sides from both groups included gastrointestinal reactions and leukopenia,which were acceptable.The adverse sides in HCPT group were no significantly higher than that of routing chemotherapeutic schemes.No patients with liver or kidney or heart function lesions were found in both groups.Conclusions A conjugation of routine chemotherapeutis schemes with HCPT may furthur increase therapeutic effects of patients with advanced neoplasms.It also took good effects on the patients who had chemotherapeutic drug-resistance.The adverse sides didn't disrupt nest chemotherapy.