摘要
用LC-MS和HPLC法以对照品对照,确定吡喹酮合成过程中产生的主要杂质是(1,11b)-位不饱和的吡喹酮,利用催化氢化法可把含该杂质过量的吡喹酮粗品转化为合格品。
The structure of the main related compound in praziquantel was determined to be 2-(cyclohexylcarbonyl)2,3,6,7-tetrahydro-4H-pyrazino[2,1-a]-iso-quinolin-4-one by LC-MS and HPLC with praziquantel reference. The relatedcompound could be transformed to praziquantel by catalytic hydrogenation.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2004年第6期358-359,共2页
Chinese Journal of Pharmaceuticals
关键词
吡喹酮
杂质
催化氢化
praziquantel
related compound
catalytic hydrogenation
