卡维地洛治疗充血性心力衰竭及其抗氧自由基作用的研究

Carvedilol Treatment on Patients with Congestive Heart Failure and Its Function of Antioxygen Free Radical

目的 研究卡维地洛治疗充血性心力衰竭的效果及其抗氧自由基的作用。方法 选取 6 5例充血性心力衰竭患者随机分为试验组 (34例 )和对照组 (31例 ) ,试验组给予常规药物 (强心剂、利尿剂、血管紧张素转化酶抑制剂 )加卡维地洛治疗 ,对照组给予常规药物加美托洛尔治疗 ,共 12周。两组患者治疗前后分别进行心脏超声检查评价心功能并测定血浆丙二醛水平。结果 治疗前两组患者心功能及血浆丙二醛水平无显著性差异。治疗 12周后两组患者心功能较治疗前均有改善 (P <0 0 5 ) ;试验组血浆丙二醛水平较治疗前明显降低 (P <0 0 5 ) ,而对照组血浆丙二醛水平无明显改变。结论 卡维地洛不仅可改善充血性心力衰竭患者心功能状况 。

Objective To investigate the clinical effect of carvedilol treatment on patients with congestive heart failure (CHF) and its function of antioxygen free radical. Methods 65 patients with CHF were randomly divided into test group (34 cases) and control group (31 cases). The patients in test group were treated with carvedilol and conventional therapy (digoxin , diuretics , ACEI ) for 12 weeks, the patients in control group were treated with metoprolol and conventional therapy for 12 weeks. The cardiac function measured by echocardiography and the level of plasma malondialdehyde (MDA) were determined at baseline for 12 weeks. Results The cardiac function and the level of plasma MDA at baseline had no difference between the two groups. The improvement of cardiac function over the short-term was similar in both groups. The level of plasma MDA was significantly reduced in the test group after 12 weeks, whereas there were no significantly changes in the control group. Conclusion Carvedilol has significant antioxidant property in addition to improving cardiac function in CHF.