小分子化合物Salen-Mn的合成及其结构测定

Synthesis and structure of the Salen-Mn compound

目的合成一种化合物 ,并对其结构及活性进行测定。方法采用回流方法 ,在实验室合成化合物 ,并通过质谱、红外光谱、核磁共振氢谱分析法对其结构进行检测 ,并用黄嘌呤氧化酶法测定此化合物的超氧化物岐化酶 (SOD)酶活性。结果质谱分析确定此化合物分子量为 3 5 6,红外光谱分析此化合物含有的官能团有 OH、C =N和苯环的存在 ,核磁共振氢谱分析证明有金属顺磁性物质锰 (Mn)的存在 ,并具有一定的SOD酶活性。结论可合成一种低分子量的具有SOD酶活性的物质。

ObjectiveTo synthesize metal complex that exhibits superoxide dismutase (SOD)-like activity and determine its structure.MethodsThis chemical compound was synthesized by means of reflux in laboratory.Its structure was examined by infrared spectra (IR),nuclear magnetic resonance hydrogen spectra(H-NMR) and mass spectra (MS).The activity of the SOD was determine by xanthine oxidase (XOD).ResultsThe IR indicted that this complex showed a typical absorption band of -OH,C=N and benzene. The H-NMR reveals the existence of metal ion manganese (Mn 3+ ,paramagnetic). The molecular weight was 365, which was obtained by EI-MS analysis. And this complex showed SOD-like activity.ConclusionA metal complex with low molecular weight and SOD-like activity has been synthesized.