郁星菖志汤对急性脑卒中后抑郁症患者血清去甲肾上腺素和5-羟色胺的影响

Effect of Yuxingchangzhi Decoction on level of norepinephrine and 5-hydroxyptamin in serum of patients with post-stroke depression

目的评价中药复方郁星菖志汤对急性脑卒中后抑郁症患者血清去甲肾上腺素 (NE)、5 羟色胺 (5 HT)的影响。方法对 76例急性脑卒中后抑郁症患者分别给予郁星菖志汤和安慰剂 ,疗程 4周。治疗前后 ,分别应用汉密尔顿抑郁量表评估疗效 ,同时测定外周血清NE、5 HT水平。结果治疗前后 ,郁星菖志汤组汉密尔顿抑郁量表评分比较有非常显著性差异 (P <0 0 1) ,安慰剂组无显著性差异 (P >0 0 5 ) ;治疗前后 ,郁星菖志汤组外周血清NE、5 HT水平比较有非常显著性差异 (P <0 0 1) ,安慰剂组无显著性差异 (P >0 0 5 )。结论郁星菖志汤能明显改善急性脑卒中后抑郁症患者外周血清NE、5 HT水平和改善抑郁症状。

ObjectiveTo evaluate the effect of Yuxingchangzhi Decoction on level of norepinephrine (NE) and 5-hydroxyptamin (5-HT) in serum of patients with post-stroke depression. Methods76 patients with post-stroke depression were treated with Yuxingchangzhi Decoction or placebo for 4 weeks. Before and after treatment, all the patients were evaluated with the Hamilton Rating Scale for Depression (HAMD),while the level of NE and 5-HT in serum of patients were measured.ResultsThe total score of HAMD of the patients of Yuxingchangzhi Decoction group was significantly different before and after treatment ( P <0.01),while that of the placebo group was not significantly different ( P >0.05). The NE and 5-HT level in serum of patients of the Yuxingchangzhi Decoction group were significantly different before and after treatment ( P <0.01),but that of the placebo group was not significantly different ( P >0.05). ConclusionYuxingchangzhi decoction can raise NE,5-HT level in patients with post-stroke depression and alleviate symptoms of depression significantly.