固体分散体提高银杏叶片溶出度的研究

Improvement of the dissolution rate of Ginkgo biloba tablets by using solid dispersion methods

目的:通过制备固体分散体提高银杏叶片中银杏叶提取物(EGb)的溶出度。方法:采用溶剂熔融法、喷雾干燥法制备聚乙二醇6000(PEG 6000)和聚乙烯吡咯烷酮K17(PVPK17)2种载体材料、不同比例的固体分散体,并比较固体分散体、物理混合物和EGb、市售普通片的溶出特性。对EGb-PEG 6000固体分散体进行差示热扫描(DSC)分析。结果:溶剂熔融法和喷雾干燥法可制备不同比例的PEG 6000,PVPK17的EGb固体分散体。EGb-PEG 6000(1:2)固体分散体片溶出度增加明显,且增溶效果优于EGb-PVPK17固体分散体。结论:EGb-PEG 6000(1:2)固体分散体能有效提高银杏叶片的溶出度。

Objective:To improve the dissolution rate of extraction of Ginkgo biloba (EGb) tablets. Methods:Two carriers (PEG 6000 and PVPK17) and solid dispersions in different ratio were prepared by solvent-melting or spray-drying technique. The dissolution characteristics of solid dispersion, mechanical mixtures,EGb and Ginkgo biloba tablets obtained from market were compared. The EGb-PEG 6000 solid dispersion were studied by differential scanning calorimetry. Results: EGb-PEG 6000 and EGb-PVPK17 solid dispersion of different ratio can be prepared by solvent-melting or spray-drying technique. The dissolution rate of EGb-PEG 6000(1: 2) were significantly improved and the im-provement was superior to EGb-PVPK17. Conclusion: The clissolution rate of EGb tablets can be effec-tively improved by preparation of EGb-PEG 6000 (1:2) solid dispersion.