高血压脑出血患者血清胃泌素变化与应激性溃疡的关系

Relation between Serum Gastrin Change and Stress Ulcer in Patients with Hypertensive Encephalorrhagia

目的 探讨高血压脑出血患者血清胃泌素 (Gas)变化及与应激性溃疡出血关系。方法 4 7例高血压脑出血患者 ,根据发病后是否合并应激性溃疡出血分为 :出血组及无出血组 ,用放射免疫法分别于入院时、第 3,7,2 1天测定血清Gas含量并与正常健康人进行对照。结果 高血压脑出血早期血清Gas含量均明显高于健康对照组 (P <0 .0 1 ) ;第 3～ 7天达高峰 ,发病后1周内出血组与无出血组间差异非常明显 (P <0 .0 1 ) ;随着病情好转 ,血清Gas值逐渐下降 ,但发病后 3周 ,出血组血清Gas水平仍明显高于未出血组 (P <0 .0 1 )。结论 血清Gas浓度与病情程度及应激性溃疡出血呈正相关 。

Objective To discuss the relation between serum gastrin level and stress ulcer bleeding in patients with hypertensive encephalorrhagia. Methods 47 patients with hypertensive encephalorrhagia were divided into hemorrhagic group and non hemorrhagic group according to whether they suffered from stress ulcer bleeding after the onset or not. Their serum gastrin level was measured through radioimmunoassay at once, and in 3, 7 and 21 days after admittance to hospital, and then compared with that of normal ones. Results The serum gastrin level of hypertensive encephalorrhagia, which reached its peak in 3～7 days, was clearly higher than that of normal controls at early stage ( P <0.01), and there was clear difference in its level between hemorrhagic and non hemorrhagic group within one week, i.e. the former was higher ( P <0.01). Serum gastrin level decreased gradually due to the improvement of the disorder, but there still was clear difference between hemorrhagic and non-hemorrhagic group in three weeks ( P <0.01). Conclusion Serum grastrin level has positive correlation with not only the severity of the disorder, but stress ulcer bleeding as well. It is suggested that dynamic measurement of gastrin be important in the course of estimating and prognosing the condition of hypertensive encephalorrhagia.