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反相高效液相色谱法测定替硝唑片剂的含量 被引量:1

Determination the Content of Tinidazole Tablets by RP-HPLC
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摘要 目的 采用反相高效液相色谱法测定替硝唑片剂的含量。方法 采用ZORBAXSB -C18色谱柱 (4 .6× 15 0mm ,5 μm) ,以乙腈 - 1%醋酸溶液 (2 0∶80 ) (pH3.5 )作为流动相 ,流速为 1.0ml/min ,检测波长 2 78nm ,检测灵敏度 0 .0 4AUFS。结果 反相高效液相色谱法测定替硝唑的线性范围是 5~ 30 μg·ml-1,r=0 .9992 ,RSD 为 2 .84 % (n=5 ) ,平均回收率为 10 0 .4 7%。结论 采用反相高效液相色谱法测定替硝唑片剂含量 ,方法简便 ,快速 ,准确 。 Aim A RP-HPLC method was established for determination the content of tinidazole tablets.Methods The separation was performed on a ZORBAX SB-C 18 column(4.6×150mm,5μm).The mobile phase was composed of acetonitrile-1% acetum 20∶80(pH 3.5).The flow rate was 1.0ml/min.The detection was carried out with a UV detector at 278nm,AUFS=0.04.Results The calibration curves were linear between 5~30μg·ml -1 (r=0.999 2).Intra-day RSD was 2.84%(n=5).Aerage recycle bin was 100.47%.Conclusion The method is simple,rapid,accurate and is suitable for determination the content of tinidazole tablets.
出处 《解放军药学学报》 CAS 2004年第3期226-228,共3页 Pharmaceutical Journal of Chinese People's Liberation Army
关键词 反相高效液相色谱法 含量测定 替硝唑片剂 回收率试验 Tinidazole RP-HPLC Determination
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  • 1Anjaneyulu.R,Guptesa.Single-Dose Treatment of Trichomonal vaginitis;A Comparison of Tinidazole and Metronidazole[J].The Joural of International Medical Research,1997,5:438
  • 2Butlerk.1-(lower alkyl) sulfonylalkyl-2(lower alkyl)-5-nitro-imidazoles[J].Vspat,1968,3,376,311
  • 3日本国家药典委员会.日本药局方(12版)[S].,1991.557.

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