莨菪类生物碱对吗啡依赖小鼠痛阈影响的比较

Comparison among the effects of Belladonna alkaloid on pain threshold of morphine-dependent mice

目的:观察莨菪类生物碱对吗啡依赖小鼠痛阈的影响。方法:连续腹腔注射吗啡(10mg/kg,1次/d,共7d)建立小鼠依赖模型,并腹腔注射莨菪类生物碱(4mg/kg,1次/d,共7d)。结果:吗啡组小鼠痛阈明显下降。东莨菪碱能显著提高吗啡依赖小鼠的痛阈。同剂量山莨菪碱和阿托品均有对抗吗啡依赖小鼠的痛阈下降的现象。结论:莨菪类生物碱中,东莨菪碱在提高吗啡依赖小鼠痛阈的作用最强。

AIM:To observe the effects of Belladonna alkaloid on pain threshold of morphine(Mor) dependent mice. METHODS:The Mor dependent mice model was established by continuous intraperitoneal injection of Mor (10 mg/kg, once a day for 7 days) and Belladonna alkaloid (4 mg/kg, once a day for 7 days). RESULTS:The pain threshold of Mor dependent mice was obviously decreased.Scopolamine could significantly advance pain threshold of Mor dependent mice. Same dose anisodamine hydrobromide and atropine antagonized the effects induced by Mor. CONCLUSION:Scopolamine is the best in Belladonna alkaloid that advances pain threshold of Mor dependent mice.