龙胆泻肝汤对小鼠的镇痛作用

Analgesic Effects of Longdan Xiegan Decoctions on Mice

目的 :观察龙胆泻肝汤的镇痛作用。方法 :(1)扭体法 :腹腔注射 0 .6 %的醋酸使小鼠产生剧烈疼痛而出现扭体反应。记录腹腔注射醋酸后 15 min内小鼠的扭体反应数。 (2 )热板法 :将筛选合格的小鼠在给药后 0 .5 ,1,2 h置于热板〔温度为 (5 5 .0± 0 .5 )℃〕上 ,记录小鼠因热刺激产生疼痛反应的潜伏期。结果 :龙胆泻肝汤能明显减少小鼠的扭体反应数 ;显著延长给药后 (热板法 ) 1,2 h小鼠疼痛反应的潜伏期。结论 :龙胆泻肝汤具有显著的镇痛作用。

Objective:To investigate the analgesic effects of Longdan Xiegan Decoctions on mice.Methods:Two kinds of animal pain models were prepared.(1)Torsion response:The Torsion response was induced by the drastic pain after intraperitoneal injection of 0.6% acetic acid.The number of torsion response was recorded within 15 minutes after intraperitoneal injection of acetic acid.(2) Hot plate:The eligible mice (after screening)were put on the hot plate (its temperature is at 55.0± 0.5℃) alone at 0.5 h,1 h,2 h after last administration.The latent period of pain response also was recorded.Results:The Longdan Xiegan Decoctions could obviously reduce the numbers of torsion response and markedly prolonge the latency of pain response at 1 h,2 h.Conclusion:These results suggest that the Longdan Xiegan Decoctions have significant analgesic effects.