摘要
目的 探讨血小板活化因子 (plateletactivitingfactor ,PAF)受体拮抗剂海风藤酮对活体实验性脑梗死大鼠脑组织氮 乙酰天门冬氨酸 (NAA)及乳酸 (LacticAcid ,Lac)等代谢产物的影响。方法 建立活体动物大脑中动脉栓塞再灌模型 ,采用磁共振波谱技术 ,分别对缺血再灌注组及海风藤酮、银杏苦内酯治疗组鼠脑组织NAA及Lac等代谢产物变化进行观察和比较。结果 在缺血 60min再灌注 1h、3h、6h海风藤酮均能有效减少脑缺血后Lac (PCr +Cr)比值的上升和NAA (PCr+Cr)比值的下降 ,与银杏苦内酯治疗组比较无差异。
Objective To observe the effect of Chinese traditional medicine Kadsurenone on the concentration of NAA and lactate after cerebral ischemia and reperfusion in rat. Methods Animal models of cerebral ischemia were established by middle cerebral artery occlusion (MCAO). Compared with ischemia/reperfusion and Ginkgolide treated groups, we observed the changes of NAA and lactate in Kadsurenone treated group by 1H MRS examination. Results Kadsurenone could decrease the concentration of lactate and prevent the decline of the concentration of NAA after cerebral ischemia/reperfusion. Conclusion As platelet activating factor receptor antagonists, both Kadsurenone and Ginkgolides showed remarkable neuroprotective effect.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2004年第6期333-335,共3页
Chinese Journal of Physical Medicine and Rehabilitation
基金
卫生部重点装备基金项目 (No .2 0 0 1 2 4 33)
国家自然科学基金资助项目 (No .39870 2 60 )
波谱与原子分子物理国家重点实验室资助项目 (No .T1 52 2 0 8)
