氟伐他汀对血管内皮依赖性舒张功能的影响

Effect of Fluvastatin on Endothelium-Dependent Dilation Function

目的 :观察氟伐他汀对于血管内皮依赖性舒张功能的影响。方法 :选取高胆固醇血症的患者 3 5例作为试验组 ,正常对照组 2 5例。试验组患者进行 8周氟伐他汀 40mg/d ,口服治疗。对 3 5例高胆固醇血症患者采用彩色多普勒超声诊断仪测定其用药前以及用药 8周后的反应性充血时和含服硝酸甘油后的肱动脉内径的变化 ;同时采用生化技术测定其血清一氧化氮 (NO)及一氧化氮合酶 (NOS)水平。结果 :①高胆固醇血症患者的血管内皮依赖性舒张功能、血清NO和NOS水平较正常人明显降低 (P <0 0 1)。②经过 8周的氟伐他汀治疗后 ,试验组的血清甘油三酯、总胆固醇和低密度脂蛋白胆固醇显著降低 ,而高密度脂蛋白胆固醇水平升高 (P <0 0 1) ,血管内皮依赖性舒张功能以及血清NO及NOS水平也较治疗前显著提高。结论 :氟伐他汀在降脂的同时可以显著改善高胆固醇血症患者的血管内皮依赖性舒张功能 ,其作用与其上调NOS的表达水平有关 。

Objective:To assess effect of fluvastatin on vascular endothelium-dependent diastolic function of hypercholesterolemia patients. Methods:Thirty five patients with hypercholesterolemia were treated with fluvastatin (40 mg/d,po) for 8 weeks. 25 healthy adults were as control group.The baseline of brachial angiobore and the changes of it at response to nitroglycerin and reactive hyperemia were measured by Dopple ultrasound before and after treatment in hypercholesterolemia patients. Blood lipids,blood concentrations of NO and NOS were also measured before and after treatment. Results:①In patients with primary hypercholesterolemia the vascular endothelium-dependent dilation function (EDD)was much reduced as compared with the control, so as for blood concentrations of NO and NOS. ② Serum total cholesterol,low density lipoprotein cholesterol and triglycerides were significantly lowered by 8-week treatment of fluvastatin(p<0.01) . Flow-mediated vasodilation,blood concentrations of NO and NOS were higher after fluvastatin therapy than before(13.41±4.19 vs 1.83±4.47,p<0.01;56.57±15.36 vs 40.09±13.03,p<0.01;36.60±2.14 vs 31.26±2.39,p<0.01). Conclusions:Endothelium-dependent vasodilation was impaired in patients with primary hyper cholesterolemia. Short-term treatment with fluvastatin may improve impaired endothelium-dependent vasodilation by enhanced the serum concentration of NO and NOS.