血浆中糖基化终级产物水平的升高与糖尿病周围大血管并发症的关系

Advanced Glycation end Products are Associated With Diabetic Peripheral Macrovascular Complications

目的 :探讨糖基化终级产物 (AGEs)与糖尿病周围大血管并发症的相关性。方法 :本实验收集了 2型糖尿病有周围大血管并发症组 (A组 ) 3 6例病人血浆 ,2型糖尿病无周围大血管并发症组 (B组 ) 46例病人血浆 ,正常对照组 49例。采用竞争性酶联免疫吸附法分析血浆AGEs浓度。结果 :在A组中 ,AGEs浓度 [( 7 14± 1 47)U/ml]明显高于B组 [( 6 0 0± 2 2 7)U/ml,P <0 0 5 ] ,也明显高于正常对照组 [( 5 3 9± 1 2 1)U /ml,P <0 0 0 1]。以有无并发症为应变量进行多元Logistic回归分析显示 ,在调整年龄、性别及其它血管危险因素后 ,血浆AGEs浓度 >6 0 85U/ml者 ,糖尿病并发症发生的危险性增加 (风险比值为 4 93 ,95 %可信限为 1 73 4～ 14 0 79)。结论 :检验结果显示 。

Objective: Advanced glycation end products (AGEs) have been recognized as a risk factor for diabetic microvascular complications. The role of the product remains an issue of particular interest in macrovascular complication. We investigated the association between serum AGEs and diabetic peripheral macrovascular complications. Methods: Total 36 diabetic patients with and 46 without diabetic peripheral macrovascular complications and 49 normal controls were recruited. Serum AGEs were measured using ELISA method by our laboratory. The relationship between plasma AGEs and diabetic peripheral vascular complications was evaluated. Results:Serum AGE concentrations ( x±s)were higher in diabetic patients with diabetic peripheral macrovascular complications (7.14±1.47 U/ml, n=36) than that in those without the complications (6.00±2.27 U/ml, n=46,p<0.05), and that in controls (5.39±1.21,n=49,p<0.001). Multiple logistic regression analysis showed that the association remained after adjustment for age, sex and other vascular risk factors, lead to a 4.93-fold increase in risk of diabetic peripheral macrovascular complications (OR=4.93,95% CI: 1.734-14.079). Conclusion:Increased level of serum AGEs might be risk factor for peripheral macrovascular complications in patients with diabetes.