2型糖尿病患者运动及感觉神经传导速度变化与C肽的关系

Relation of the changes in motor and sensory nerve conduction velocities with C peptide in type 2 diabetics

目的:探讨2型糖尿病患者运动神经传导速度(motornerveconductionvelocity,MNCV)和感觉神经传导速度(sensorynerveconductionvelocity,SNCV)的变化与C肽水平的关系,为防治糖尿病周围神经病变提供理论依据。方法:回顾性分析73例2型糖尿病患者的MNCV和SNCV与C肽释放试验中糖负荷前及糖负荷120minC肽水平的关联性。结果:2型糖尿病患者的MNCV及SNCV正常者和异常者的下降与糖负荷120minC肽水平下降有关(t=23.15～35.46,P<0.01),与糖负荷前C肽水平下降无关(t=0.47～1.63,P>0.05)。结论:C肽水平下降可能会加速神经传导速度的下降,提示保持血中C肽水平,有可能延缓周围神经病变的进展。

AIM:To study the relationship of motor nerve conduction velocity(MNCV) and sensory nerve conduction velocity(SNCV) with C peptide in type 2 diabetics,so as to provide theoretical evidence for the prevention and treatment of diabetic peripheral neuropathy(DPN). METHODS:A retrospective study was conducted in 73 patients with type 2 diabetes to analyze the correlation of MNCV and SNCV with C peptide values before and at 120 minutes of glucose load in the C peptide release experiment. RESULTS:The reduction of normal and abnormal MNCV and SNCV was correlated with the reduction of C peptide at 120 minutes of glucose load(t=23.15-35.46,P< 0.01),but was not correlated with the reduction of C peptide before glucose load(t=0.47-1.63,P >0.05). CONCLUSION:The reduction of C peptide may accelerate the descent of NCV,which suggests that keeping serum C peptide levels may retard the progress of peripheral neuropathy in patients with type 2 diabetes.