褪黑激素与老年睡眠障碍的相关性

Relationship between melatonin and sleep disorders in elderly people

目的:证实褪黑激素缺乏与老年人睡眠障碍的关系。方法:用反相高效液相色谱(HPLC)荧光检测法对睡眠障碍组(n=43)和睡眠正常组(n=41)的老年患者尿分别进行褪黑激素检测。结果:睡眠障碍组夜间尿褪黑激素平均总量为(189.6±32.1)pmol,白天褪黑激素总量为(42.8±3.2)pmol,睡眠正常组夜间尿褪黑激素平均总量为(247.4±28.3)pmol,白天褪黑激素总量为(68.7±2.9)pmol,无论白天还是夜间,睡眠障碍组褪黑激素积累量明显低于睡眠正常组,二者之间差异具有显著性意义(t=7.24,P<0.05)。结论:褪黑激素减少可影响老年人睡眠,为临床应用褪黑激素治疗老年睡眠障碍提供理论依据。

AIM:To prove the relationship between melatonin deficiency and sleep disorders in the elderly people. METHODS:Melatonin in elderly patients in sleep disorder group(n=43) and control group(n=41) were measured with reversed high effect liquid chromatography. RESULTS:For sleep disorder group, the average value of melatonin in urine was(189.6±32.1) pmol at night and(42.8±3.2) pmol in the daytime;For normal sleep group,the average value of melatonin in urine was(247.4±28.3) pmol at night and(68.7±2.9) pmol in the daytime.No matter day or night,the results indicated that the levels of melatonin in sleep disorder group were significantly lower than that in control group.There was significantly difference(t=7.24,P< 0.05).CONCLUSION:The decrease of melatonin influences the sleep of elderly people, which provides therapeutic evidence for clinical treatment on sleep disorders in the elderly people.