针灸并用舒郁散治疗抑郁症的效果分析

Effect of the combination of acupuncture and shuyusan in the treatment of depression

目的:观察针灸及中药舒郁散治疗抑郁症的疗效及安全性,并与西药帕罗西汀进行对比研究。方法:采用美国1994年心理精神病学会抑郁症的诊断标准,将确诊为抑郁症的患者采用汉密顿抑郁量表(Hamiltonratingscalefordepression,HAMD)积分≥17分,临床表现的综合评分(clinicalglobalimpres-sions-severityofillnessscale,CGI-S)≥4.0分的70例患者随机分为中医治疗组43例(采用针灸及中药舒郁散治疗)及西药治疗组35例(口服帕罗西汀治疗),观察治疗前后两组的HAMD,CGI-S的积分变化;同时观察治疗后两组患者临床不良反应的发生率。结果:两组治疗前HAMD评分分别为(20.4±7.2)、(21.2±6.8)、治疗后分别为(9.6±5.8)、(8.9±6.2)。治疗前后自身比较(t=7.5704,7.7939,P<0.01)。两组治疗前CGI-S评分分别为(4.2±0.8)、(4.4±0.7)、治疗后分别为(1.9±1.2)、(1.8±1.4)。治疗前后自身比较(t=10.3352,9.6857,P<0.05)。中医组治疗抑郁症的有效率为4.29%(27/42),西医组的有效率为73.53%(25/34),两组有效率比较(χ2=0.7431,P>0.05),西医治疗组38.2%(13/34)的患者出现不良反应,中医治疗组11.9%(5/42)的患者出现不良反应,两组不良反应发生率比较(χ2=7.2071,P<0.01)。结论:针灸及中药舒郁散治疗抑郁症疗效与西药帕罗西汀相同,且更?

AIM:To observe the efficacy and reliability of acupuncture and traditional Chinese medicine shuyusan in treating depression,and the effect and reliability were compared with those of paroxetine. METHODS:Totally 76 patients who met the depression diagnostic criteria of American Psychiatric Association 1994 of major depression or bipolar disorder,and the score of Hamilton Depression Rating Scale(HAMD) ≥17, and the score of Clinical Global Impressions Severity of Illness scale(CGI S) ≥4.0 were divided into traditional Chinese medicine treatment group(TCM group, n=43,treated with acupuncture and TCM shuyusan) and western medicine treatment group(n=33,treated with paroxetine,paroxetine group).The changes of the scores of HAMD and CGI S,and the incidence rate of clinical adverse reaction after treatment were also observed. RESULTS:The scores of HAMD in the two groups before treatment were 20.4±7.2,21.2±6.8,and after treatment were 9.6±5.8,8.9±6.2(t=7.570 4,7.793 9,P< 0.01).The scores of CGI S in the two groups before treatment were 4.2±0.8,4.4±0.7,and after treatment were 1.9±1.2,1.8±1.4(t=10.335 2,9.685 7,P< 0.05).The effective rate in treating depression was 4.29%(27/42) in the TCM group,not significantly different from that in the paroxetine group(73.53%,25/34)(χ2=0.743 1,P >0.05).Comparing the efficacy rate between two groups,there was no significant difference. The incidence rate of adverse reaction was 38.2￡$￡¨13/34￡(c)in the paroxetine group and 11.9￡$￡¨5/42￡(c)in the TCM group,and there was significant difference(χ2=7.207 1,P< 0.01).CONCLUSION:Acupuncture and traditional Chinese medicine shuyusan have the same curative effect with paroxetine in treating depression with the advantages of more safety and less adverse reaction.