降钙素与碳酸钙复方制剂对老年性骨质疏松症的治疗效用:2年随访

Therapeutic effect of Miacalcic and Caltrate D on senile osteoporosis:a 2 year follow up

目的:观察降钙素与碳酸钙复方制剂治疗老年性骨质疏松症(osteoporosis,OP)的疗效。方法:集取老年性OP患者60例,随机分降钙素组30例,碳酸钙复方制剂组30例,比较两种药物治疗前后桡骨远端骨密度的变化及对老年性OP治疗的总有效率。结果:降钙素治疗后1年随访,总有效率为77%,骨密度增加率为2.88%,与碳酸钙复方制剂组比较差异有显著性意义(P<0.05);治疗后2年随访,总有效率为97%,骨密度增加率为3.88%,且无不良反应,与碳酸钙复方制剂组比较差异有非常显著性意义(P<0.01)。结论:降钙素与碳酸钙复方制剂比较,治疗老年性OP的效用更为明显,且无不良反应,值得临床推广应用。

AIM:To observe the therapeutic influence of Miacalcic and Caltrate D on senile osteoporosis(OP). METHODS:Sixty patients with senile OP were randomly divided into 2 groups:Miacalcic group(n=30) and Caltrate D group(n=30).The changes of bone mineral density(BMD) of distal radius and the total effective rate of two drugs before and after treatment were compared. RESULTS:One year follow up after treatment,the total effective rates was 77%,and the increasing rate of BMD was 2.88%in the Miacalcic group,significantly different from those in the Caltrate D group(P< 0.05). Two year follow up after treatment,the total effective rates was 97%,the increasing rate of BMD was 3.88%,and there was no side effect in the Miacalcic group,and the differences were very significant as compared with those in the Caltrate D group(P< 0.01). CONCLUSION:Compared with Caltrate D,Miacalcic has more obvious effect in treating senile OP,and has no side effect.It is worthy being widely spread for clinical application.