伴2型糖尿病的老年男性部分雄激素缺乏综合征与骨质疏松的关系

Relationship between partial androgen deficiency syndrome with type 2 diabetes mellitus and osteoporosis in the aging male

目的:探讨伴有2型糖尿病的老年男性部分雄激素缺乏综合征(partialandrogendeficiencysynsdromeintheagingmales,PADAM)患者与骨质疏松的关系。方法:PADAM患者35例,伴2型糖尿病的PADAM患者36例,均采用放射免疫法测定游离睾酮(FT),定量CT测定骨密度(BMD),同时测定空腹和餐后2h血糖及糖化血红蛋白。结果:伴有2型糖尿病的PADAM组FT水平和BMD低于PADAM组,后者又低于对照组(P<0.001)。结论:PADAM是骨质疏松发生的重要原因,若伴有糖尿病将加重骨质疏松的程度。

AIM:To discuss the association between partial androgen deficiency syndrome in the aging males(PADAM) with type 2 diabetes mellitus(DM) and osteoporosis. METHODS:Bone mineral density(BMD) was determined by quantitative CT,and free testosterone(FT) was mensurated by radioimmunoassay,and meanwhile,fasting plasma glucose(FBG),2 hour postprandial plasma glucose and HbA1C were determined for 35 PADAM patients and 36 PADAM patients with type 2 DM. RESULTS:The levels of FT and BMD in PADAM with type 2 DM group were lower than those of PADAM group,which were lower in the latter group as compared with the control group(P< 0.001). CONCLUSION:PADAM is one of the important reasons for the occurrence of osteoporosis,and the degree of osteoporosis is aggravated if with type 2 DM.