射频消融术联合肝动脉化疗栓塞治疗肝癌的临床效果

Clinical effects of radiofrequency ablation combined with hepatic arterial chemo-embolization for treating hepatocellular carcinoma

目的 探讨射频消融术后联合肝动脉化疗栓塞对肝癌的治疗效果。方法 2 8例肝癌患者共 3 3个瘤灶 ,中等大小肿瘤 (3～ 5cm) 9个 ,大肿瘤 (>5 .1cm) 2 4个。射频消融术后 2～ 8周行肝动脉化疗栓塞术。治疗效果采用增强CT扫描和临床随访评估。结果 RFA术后CT扫描见治疗区仍有残留癌灶。TACE后CT扫描见大部分残留癌灶碘油沉积良好。 2 0例患者AFP转阴或明显下降。 2 5例临床随访 ,累计生存率 >1年 (88.0 %) ,>2年 (72 .0 %)。

Objective To evaluate the therapeutic efficacy of hepatic arterial chemo embolization (HACE) after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). Methods A total of 28 cases of HCC with 33 nodules [9 intermediate nodules (3-5 cm) and 24 large nodules (> 5.1 cm)] were observed. The patients received TACE within 2-8 weeks after RFA. The therapeutic efficacy of the treatment was evaluated by enhanced CT scan and clinical follow up. Results Residual nodules were found in the treated areas after RFA by enhanced CT scan. Most of the residual nodules were well filled with lipiodol after TACE. AFP turned negative or decreased obviously in 20 cases. The follow up showed that one year and two year survival rates were 88.0% and 72.0%, respectively. Conclusion The combined therapy of RFA with TACE is an effective method for the treatment of HCC.