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白细胞介素12在DNA疫苗中的分子佐剂效应

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摘要 白细胞介素 12 (IL- 12 )作为分子佐剂 ,可促进或抑制 DNA疫苗的免疫效果。本文就近年来 IL- 12作为分子佐剂应用于多种传染病和肿瘤 DNA疫苗的研究进展作一综述。
作者 李晖 钟森 任红
机构地区 重庆医科大学第二临床学院 泸州医学院附属医院感染病科
出处 《国外医学（预防．诊断．治疗用生物制品分册）》 2004年第4期165-170,共6页 Foreign Medical Sciences(Section of Bilogics for Prophylaxis,Diagnosis and Therapy)
基金 四川省青年科技基金 [川青科基 ( 2 0 0 2 ) 1号 ]
关键词 白细胞介素12 分子佐剂 DNA疫苗
分类号 R392.1 [医药卫生—免疫学]
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参考文献31

  • 1Chen HW, Pan CH,Huan HW, et al. Suppression of immune response and protective immunity to a Japanese encephalitis virus DNA vaccine by coadministration of an IL-12-expressing plasmid. J Immunol,2001,166: 7419-7426.
  • 2Leutenegger CM, Boretti FS, Mislin CN, et al. Immunization of cats against feline immunodeficiency virus (FIV) infection by using minimalistic immunogenic defined gene expression vector vaccines expressing FIV gpl40 alone or with feline interleukin-12(IL-
  • 3Boretti FS, Leutenegger CM, Mislin C, et al. Protection against FIV challenge infection by genetic vaccination using minimalistic DNA constructs for FIV env gene and feline IL-12 expression. AIDS,2000,14:1749-1757.
  • 4Martin E, Kamath AT, Briscoe H, et al. The combination of plasmid interleukin-12 with a single DNA vaccine is more effective than Mycobacterium bovis (bacilli Calmette-Guerin) in protecting against systemic Mycobacterium avium infection. Immunology,2003,1
  • 5Palendira U, Kamath AT,Feng CG, et al. Coexpression of interleukin-12 chains by a selfsplicing vector increases the protective cellular immune response of DNA and Mycobacterium bovis BCG vaccines against Mycobacterium tuberculosis. Infect Immun, 2002,70:1
  • 6Matsui M, Moriya O, Akatsuka T. Enhanced induction of hepatitis C virus-specific cytotoxic T lymphocytes and protective efficacy in mice by DNA vaccination followed by adenovirus boosting in combination with the interleukin-12 expression plasmid. Vaccine,
  • 7Chow YH, Chiang BL, Lee YL, et al. Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by eodelivery of various cytokine genes. J Immunol, 1998,160:1320-1329.
  • 8Sin JI, Kim JJ, Boyer JD, et al. In vivo modulation of vaccine-induced immune responses toward a Th1 phenotype increases potency and vaccine effectiveness in a herpes simplex virus type 2 mouse model. J Virol, 1999,73:501-509.
  • 9Sin JI, Kim JJ, Arnold RL, et al. IL-12 gene as a DNA vaccine adjuvant in a Herpes mouse model: IL-12 enhances Th1-type CD4+T cell-mediated protective immunity against Herpes simplex virus-2 challenge. J Immunol, 1999,162:2912-2921.
  • 10Sakai T, Hisaeda H, Nakano Y, et al. Gene gunbased co-immunization of merozoite surface protein-1 cDNA with IL-12 expression plasmid confers protection against lethal Plasmodium yoelii in A/J mice.Vaccine, 2003,21:1432-1444.

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国外医学（预防．诊断．治疗用生物制品分册）
2004年 第4期

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