胃癌患者的染色体畸变分析

An Analysis of Chromosome Aberrance of the Gastric Cancered

背景与目的 :研究胃癌患者的染色体畸变情况。材料与方法 :以临床已确定的未经放疗和化疗的26例胃癌患者作为研究组 ,以健康、无不良嗜好、无有害物接触史的志愿者26人作为对照组。采取研究组和对照组中每一例的外周血样本 ,各培养3个培养物 ,分别用于进行微核率、姐妹染色单体交换率、染色体结构和数目畸变率等指标的研究。 结果 :研究组均高于对照组 ,显示出研究组和对照组的微核率、染色单体交换率、染色体畸变率均存在着差异性。结论 :染色体畸变可能是胃癌发生的细胞学基础。

ABACKGROOND ALM: Research on the chromosome aberrance of the gastric cancer. MATERIAL AND MOTHDS: Regard26gastric cancered patients as a research group,diagnosed with no radioactive and chemical theˉatments.Regard26volanteers as contrast group.Use3culture medium which cultivate through each of circumjacent hema-sampling from both group for the research on microkernel rate,sibling chromatid exchanged rate and chroˉmosome aberrance rate of the configuration and number. RESULT: The rates on the research group significantly higher than that on the contrast group.Via statistical analysis and process,χ 2 test P<0.01which suggest that there are notable discrepancy on both groups. CONCLUSION: Chromosome aberrance probably are the cytological elements causing gastric cancer.