2-巯基-5-甲氧基-1H-苯并咪唑的合成工艺的改进

Improvement on Synthetic Technology of 2-mercatto-5-methoxy-1H-benzimidazole

目的 对 2 -巯基 - 5 -甲氧基 - 1H -苯并咪唑的合成工艺进行改进。方法 以对氨基苯甲醚为原料 ,经氨基保护后硝化得 2 -硝基 - 4 -甲氧基乙酰苯胺 ,然后酰胺基水解得 2 -硝基 - 4 -甲氧基苯胺 ,再将硝基还原为氨基得 4 -甲氧基 - 1,2 -苯二胺 ,最后环合得 2 -巯基 - 5 -甲氧基 - 1H -苯并咪唑。结果 此法得到的 2-巯基 - 5 -甲氧基 - 1H -苯并咪唑质量、收率高 ,成本低。结论 此法简化了操作 。

Objective The improve the synthetic technology of 2-mercatto-5-methoxy-1H-benzimidazole. Methods The improvement was carried out in synthesizing the 2-roercatto-5-methoxy-1H-benzimidazole. The target from paminocanisole by protecting the amino-group first,then nitrofying,hydrolysizing aeylamide,reducting nitryl and cyclizating. Results The reaction method improved made the quality better,the yield higher and the cost lower. Conclusions The method was simple and convenient for synthesizing 2-mercatto-5-methoxy-1H-benzimidazole,and so the process was feasible in industry.