逆向疫苗学及其研究进展

Reverse vaccinology and its advance in research for developing novel vaccines

基于基因组的疫苗研发途径被称为逆向疫苗学 ,它不仅省时、经济 ,而且可为传统方法难于或根本无法开展的疫苗研究提供新的解决方法。逆向疫苗学的研究过程始于硅片 ,用计算机预测疫苗的所有抗原 ,不依赖于抗原是否丰富 ,也不需要微生物是否能够体外培养。本文介绍逆向疫苗学的概况 ,特别是近年来在研制某些病原菌新疫苗方面的进展。

A genome-based approach to vaccine development, which was named as “reverse vaccinology”, reduces the time and cost required for the identification of candidate antigens and provides new solutions for those vaccines which have been difficult or impossible to develop with conventional approaches. This approach allows for the design of vaccines starting from the prediction of all antigens in silico, independent of their abundance and without the need to grow the microorganism in vitro. This review introduces the application of this strategy to develop novel vaccines against some human pathogens.