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双膦酸作为骨靶向载体治疗骨质疏松症的研究进展 被引量：4

Bisphosphonates as Bone-targeted Agents to Treat Osteoporosis
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摘要 综述了以双膦酸作为骨靶向载体转运其它药物治疗骨质疏松症的研究进展。骨质疏松症是一种在绝经后妇女中最为常见的疾病。目前使用的药物大部分存在着副作用大的缺点 ,所以需要研制能选择性作用于骨组织的药物。双膦酸类化合物有较好的趋骨性 。 Osteoporosis is among the most significant disorders affecting the postmenopausal female population. Because of the shortcoming of side effects, there is a need for the drugs that only have selective effects on bone tissue. Bisphosphhonates exhibited an exceptional affinity to bone, which led to the utility for targeting pharmacological agents to bone. This article is intended to summarize research and development in bisphosphonates as bone-targeted agents used in the treatment of osteoporosis.
作者 王军波 谢毓元
机构地区 中国科学院上海生命科学研究院上海药物研究所
出处 《药学进展》 CAS 2004年第7期294-299,共6页 Progress in Pharmaceutical Sciences
关键词 双膦酸 骨靶 载体 骨质疏松症 代谢性骨疾病 Bisphosphonates,Osteoporosis,Bone-targeted
分类号 R58 [医药卫生—内分泌]
  • 相关文献

参考文献28

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二级参考文献17

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药学进展
2004年 第7期

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