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雌激素合成及代谢酶与乳腺癌易感性的研究 被引量：6

A Study of Relationship between Estrogen Synthesis and Metabolism Involved Enzymes and Breast Cancer Susceptibility
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摘要 全文总结雌激素合成代谢的全过程,并对已报道的雌激素合成及代谢相关酶与乳腺癌易感性的研究进行简单的综述分析。 s:This paper reviewed the synthesis and metabolism procedure of estrogen and focused on the progress in the studies on the relationship between these enzymes and breast cancer susceptibility.
作者 黄平 周宏灏
机构地区 湖南省肿瘤医院 中南大学临床药理研究所
出处 《肿瘤学杂志》 CAS 2004年第4期267-270,共4页 Journal of Chinese Oncology
关键词 雌激素 酶 乳腺肿瘤 易感性 estrogen enzyme breast neoplasms susceptibility
分类号 R737.9 [医药卫生—肿瘤]
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参考文献25

  • 1[1]Kristensen VN, Kure EH, Erikstein B, et al. Genetic sus ceptibility and environmental estrogen-like compounds[J]. Mutat Res, 2001,482:77-82.
  • 2[2]Zhou BT, Conny A. Functional role of estrogen metabolism in target cells: review and perspectives[J]. Carcinogenesis, 1998,19:1-27.
  • 3[3]Murray GI, Taylor MC, McFadyen MC, et al. Tumour specific expression of cytochrome P450 CYP1B1 [J]. Cancer Res, 1997, 57:3026-3031.
  • 4[4]Feigelson HS, Coetzee GA, Kolonel LN, et al. A polymorphism in the CYP17 gene increases the risk of breast cancer[J]. Cancer Res, 1997,57:1063-1065.
  • 5[5]Feigelson HS, Shames LS, Pike MC, et al. Cytochrome P450c17alpha gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations [J]. Cancer Res, 1998,58:585-587.
  • 6[6]Kristensen VN, Borresen-Dale AL. Improved electrophore tic separation of polymorphic short tandem repeats in agarose gels using bis-benzimide[J]. Biotechniques, 1997, 23:634-636.
  • 7[7]Kristensen VN, Harada N, Yoshimura N, et al. Genetic variants of CYP19 (aromatase) and breast cancer risk[J]. Oncogene, 2000,19:1329-1333.
  • 8[8]Vihko P, Isomaa V, Ghosh D. Structure and function of 17beta-hydroxysteroid dehydrogenase type 1 and type 2 [J]. Mol Cell Endocrinol, 2001,171:71-76.
  • 9[9]Labrie F, Luu-The V, Lin SX, et al. Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease[J]. J Mol Endocrinol, 2000, 25:1-16.
  • 10[10]Shiba E, Taguchi T, Tamaki Y, et al. Involvement of up regulation of 17beta-hydroxysteroid dehydrogenase type 1 in maintenance of intratumoral high estradiol levels in postmenopausal breast cancers[J]. Int J Cancer, 2001,94: 685-689.

同被引文献87

引证文献6

二级引证文献16

肿瘤学杂志
2004年 第4期

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