左氧氟沙星联合卷曲霉素治疗耐多药结核疗效评价

Therapeutic effect and evaluation of levofloxacim and pasimiazid on treating MDR-TB

目的 观察左氧氟沙星 (V)联合卷曲霉素 (C)方案对耐多药结核病 (MDR- TB)的疗效。方法 132例 MDR- TB患者随机分为治疗组 6 6例和对照组 6 6例。化疗方案分别为 3VCL THZ/6 CVL,3L KZTHE/6 THL E。结果 9个月后 ,治疗组涂阳阴转率 6 7% ,培阳阴转率 72 % ;对照组涂阳阴转率 2 7% ,培阳阴转率 33%。痰菌阴转率治疗组显著高于对照组 (P<0 .0 5 )。结论 含左氧氟沙星联合卷曲霉素治疗 MDR- TB,疗效满意。

Objective To observe the therapeutic effects in the treatment of MDR-TB with levofloxacim and Capreomycin. Methods A total of 131 cases were divided into two groups in a randomized way: the study group (n=66) and the control group (n=66). The groups were 3VCLTHZ/6CVL and 3LKZTHE/6THLE for the study and control groups, respectively. Results Nine months later, the sputum negative conversion rate in smear and the rate in cuture was, respectively, 67% and 72% in the study group, 27% and 33%, respectively, in the control group. The conversion rate in the study group is significantly high than that in the control group: P<0.05.Conclusion Significant results were achieved when choosing levofloxacin and capreomycin for treating MDR-TB.