肝癌中P27的表达及其意义

Expression and significance of P27 in hepatocellular carcinomas

目的 :研究P2 7蛋白在肝细胞癌中的表达和意义。方法 :选取经手术治疗的肝癌患者标本 5 0例 ,癌旁组织 2 2例 ,正常肝组织 9例 ,用免疫组化方法检测这些组织中P2 7表达指数 (P2 7LI)。结果 :肝癌组织中P2 7LI比癌旁组织高 (P =0 .0 0 2 ) ,而癌旁组织比正常对照肝组织高 (P =0 .0 0 7)。P2 7蛋白的表达与肿瘤的分化、分期、肿瘤直径大小以及有无门静脉侵犯和有无肝内转移相关。P2 7LI≥ 5 0 %的肝癌患者术后生成时间明显延长 (P =0 .0 0 4 )。结论 :P2 7在早期肝癌中有阻止癌细胞增殖的作用 ,其在肝癌组织中的表达有助于判断肿瘤的进展程度 。

Objective:To study the expression and its significance of P27 protein in hcpatocellular carcinomas(HCC).Methods:Expression of P27 protein is investigated by immunohistochemistry technique(SP) in 50 cases of hepatocellular carcinoma who had undergone surgery for HCC,22 cases of their adjacent noncancerous lesions and 9 cases normal liver control specimens.Results:The P27 LI in hepatocellular carcinomas was higher than that in the adjacent noncancerous lesions (P=0.002).Furthermore,the P27LI in adjacent noncancerous lesions was significantly highter than that in normal liver lesions (P=0.007).The expression of P27 was significantly correlated with tumor differentiation,stage,size,portal invasion,and intrahepatic metastasis.The post-operation survival time for patients with P27LI≥50% was longer than those with P27 LI<50%'s (P=0.004).Conclusion:These findings suggest that in HCC P27 is active against HCC progression in early phases and may be helpful in determining tumor progression.And it may serve as an available prognostic marker.