甲亢^(131)Ⅰ治疗后垂体-甲状腺轴平衡的恢复过程初探

The recovery course of pituitary-thyroid axis after ^(131)Ⅰin hyperthyroidism

目的 :探讨甲亢13 1Ⅰ治疗后垂体 -甲状腺轴平衡的恢复过程 ,以指导甲亢13 1Ⅰ治疗后的随访治疗。方法 :对我科 1997～ 2 0 0 0年行住院13 1Ⅰ治疗的甲亢病人 32 2例定期随访 ,并测定血清T3 、T4和TSH ,随访时间 3年。结果 :13 1Ⅰ治疗后 ,甲亢病人血清甲状腺激素和TSH浓度恢复正常的百分概率均逐渐升高 ,TSH恢复正常的时间明显落后于甲状腺激素恢复正常的时间 ;部分病例在 4～ 6月有一过性甲低 ,但绝大多数病例在 1年左右恢复正常。结论 :甲亢病人经13 1Ⅰ治疗后 ,甲亢症状基本在1年内得到控制 ,但其垂体

Objective:To review the recovery course of pituitary-thyroid axis by follow-up of hyperthyroidism patients with ^(131)Ⅰ therapy.Methods:This study involved 322 patients undergoing^(131)Ⅰ therapy between 1997 and 2000 in our hospital.Serum T_3,T_4 and TSH were regularly evaluated for 3 years after therapy.Results:Our study showed that serum T_3,T_4 and TSH returned to normal levels step by step,but the recovery of TSH fell behind that of T_3 and T_4.Conclusion:Our study demonstrates that clinical manifestations disappear in 1 year after ^(131)Ⅰ therapy,while the recovery of pituitary-thyroid axis takes more time.