万拉法新、氯丙咪嗪对抑郁症患者生活质量的影响

A comparative study of quality of life in depression with venlafaxine and chlorimipramine

目的 :探讨万拉法新、氯丙咪嗪对抑郁症患者生活质量的影响。 方法 :对符合CCMD -Ⅲ诊断标准的抑郁症患者 ,随机分成两组 ,在分别使用万拉法新 ( 3 8例 )、氯丙咪嗪 ( 3 8例 )治疗 2个月 ,用汉密顿抑郁量表 (HAMD)观察患者的抑郁症状 ,用药物副反应量表 (TESS)观察患者的副反应严重程度 ,用生活质量综合评定问卷 (GQOLI -74)分析患者的生活质量。 结果 :发现万拉法新在改善抑郁情绪方面与氯丙咪嗪相当 ,而万拉法新的副反应少而轻。 2个月的治疗前后相比 ,万拉法新对患者的生活质量的影响 ,除物质生活维度外 ,均非常明显改善 (P<0 0 1)。而氯丙咪嗪除对心理功能有部分提高外 ,对躯体功能、社会功能均无明显改善 (P >0 0 5 )。 结论 :万拉法新组与氯丙咪嗪组相比 。

Objective: To explore the effect of quality of life in depression with venlafaxine and chlorimipramine. Methods: The patients that consistent with the diagnostic criteria of depression in CCMD-3 were randomized into two groups: venlafaxine group (38 cases) and chlorimipramine group(38cases). The course of treatment was 2 months. Before and after the treatment, the depress symptoms were evaluated by HAMD, the side effects were evaluated by TESS and the quality of life were evaluated by GQOLI-74. Results: The curative effect to improve depress symptoms in venlafaxine group was equivalency with chlorimipramine group. The side effects in venlafaxine group were fewer and lighter than chlorimipramine group. After 2 months treatment, the effect of quality of life in venlafaxine group was getting light to except material life factor (P>0.05). Conclusions:Venlafaxine is more useful for improving the quality of life of depressive patients than chlorimipramine.