腺苷脱氨酶和胆固醇的联合检测在结核性和癌性胸水中的作用

Clinical significance of defection of adenosine deaminase and cholesterol in differential diagnosis of tuberculosis and carcinomatous hydrothorax

目的探讨腺苷脱氨酶(ADA)和胆固醇(Ch)的联合检测在结核性和癌性胸水的作用。方法ADA检测用速率法,Ch采用时间终止法。结果结核性胸水组ADA含量(5.08±1.039)明显高于癌性胸水组(1.44±0.387)(P<0.05);癌性胸水组Ch含量(2.55±0.491)明显高于结核性胸水组(1.26±0.363)(P<0.05);ADA、Ch单项检测的敏感性分别为85.7％,78.6％,特异性分别为93％,87.1％;两项联合检测的敏感性为93.2％,特异性为95.7％。结论胸腔积液ADA、Ch联合检测可提高结核性和癌性胸水鉴别的准确性。

Objective To evaluate the clinical significance of detection of adenosine de aminase (ADA) and choles-teral (CH) in differential diagnosis of tuberculosis and carcinomatous hydrothorax. Method ADA was determined by enzymatic rste method. CH was determined by time-endpoint method. Results ADA was obviously higher in tuberculosis hydrothorax (5. 08±1. 039) than in carcinomatous hydrothorax (1. 44±0. 387)(P<0. 05). CH was also ob-viously higher in carcinomatous hydrothorax(2. 55 ±0. 49) than in tuburberculous hydrothorax(1. 26-+ 0. 363).The sensitivity and specificity of ADA were 85. 7%、93% and of CH were 78. 6%、87. 1% however, when the both were used simultaneously to examine, the sensitivity and specificity were improved 93. 2% and 95. 7%. Conclusion Detection of ADA and CH in hydrothorax improves the accuracy of differential diagnosis of tuburberculous hydro-thorax and carcinmatous hydrothorax.