糖尿病肾病动态血压模式的特点及其与尿蛋白的关系

24 h Ambulatory Blood Pressure Pattern In Diabetic Nephropathy and the Corelation With Uric Protein

目的 :观察糖尿病肾损害不同时期患者的血压模式的变化 ,及其在糖尿病肾病发生机制中所起的作用。方法 :分别选取血糖稳定、临床血压正常的 、 、 期 2型糖尿病肾损害患者 ,进行动态血压测定 ,观察他们日夜血压模式的特点并与正常对照组进行对比。结果 :实验组患者的共同特点为夜间血压的升高及非勺型曲线的出现率增高 ,且后者与尿蛋白的水平成正相关。结论 :糖尿病肾损害患者的血压模式的改变 ,先于血压的升高及尿蛋白的明显增多 ,提示自主神经功能的受损 ,是糖尿病肾病的发病机制之一。

Objective To investigate the 24 h ambulatory blood pressure pattern in diabetic nephropathy and the corelation with uric protein. Methods Patients in different stages of diabetic nephropathy were included in the study and a normal group was set to be the contrast. A 24 h ambulatory blood press was recorded by the monitor in every subject.The blood press parameters were analysed and compared between different groups.Results The loss of a fall in blood pressure and non-dippers phenomenon was more prevalent in diabetic subjects,and the non-dippers was corelative to uric protein. Conclusion The abnomal blood pressure pattern is a early mark and cause of diabetic nephropathy.