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奈达帕汀与其他抗癌药联用对人肝癌SMMC7721细胞株的细胞毒作用 被引量：3

Synergism in the cytotoxic effects of nedaplatin combined with adriamycin or mitomycin or Fluorouracil on human liver cancer cell line SMMC7721 in vitro
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摘要 目的 :研究奈达帕汀 (Nedaplatin)对人肝癌SMMC772 1细胞株的细胞毒作用及其与多柔比星、丝裂霉素及氟尿嘧啶三种抗癌药联用的相互作用。　方法 :用MTT比色法测定奈达帕汀单独及与多柔比星、丝裂霉素或氟尿嘧啶联合应用时的细胞毒作用。　结果 :奈达帕汀对SMMC 772 1细胞株有一定的抑制作用 (IC50 为 2 0 .1mg/L) ,其细胞毒指数与药物浓度呈正相关 ;奈达帕汀与多柔比星、丝裂霉素或氟尿嘧啶联合应用在一定剂量范围内呈现协同效应。　结论 :奈达帕汀与多柔比星、丝裂霉素及氟尿嘧啶对人肝癌SMMC772 1细胞株具有明显的协同细胞毒作用 ,可联合用于肝癌的治疗。 Objective: To investigate the suppressive effects of nedaplatin on human liver cancer cell line SMMC7721 and the interactions between nedaplatin and adriamycin or mitomycin or fluorouracil. Methods: The cytotoxic index of nedaplatin alone or combined with other chemotherapy agents on SMMC cells were detected by MTT method. Results: SMMC was sensitive to nedaplatin with a positive correlation between cytotoxic index and nedaplatin concentration. There were significant synergism in the cytotoxic effects of nedaplatin combined with adriamycin or Mitomycin or Fluorouracil on SMMC cells. Conclusion: Nedapltin is a promising agent in the treatment of human liver cancer.
作者 陈龙邦 鹿红 臧静 王晨
机构地区 南京军区南京总医院肿瘤科
出处 《医学研究生学报》 CAS 2004年第8期685-687,共3页 Journal of Medical Postgraduates
关键词 人肝癌细胞 奈达帕汀 多柔比星 丝裂霉素 氟尿嘧啶 药物相互作用 Human hepatocarcinoma cell Nedaplatin Adriamycin Mitomycin Fluorouracil Drugs interaction
分类号 R735.7 [医药卫生—肿瘤]
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参考文献6

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共引文献11

同被引文献28

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引证文献3

二级引证文献6

医学研究生学报
2004年 第8期

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