四种抗菌药物治疗中老年下呼吸道感染患者的经济学评价

Pharmacoeconomic evaluation of four therapeutic schemes for lower respiratory infection in middle-older patients

目的 :对治疗中老年患者下呼吸道感染的四种抗菌药物进行药物经济学评价。 方法 :运用药物经济学成本 效果分析法 ,对头孢唑啉、舒他西林、氧氟沙星、头孢呋辛四种药物进行回顾性分析。 结果 :各组治疗总有效率分别为 5 5 .3%、6 5 .2 2 %、73.97%和 6 9.39% (P >0 .0 5 ) ;成本分别为 130 .5 9元、10 6 4元、2 4 9.85元和 112 6 .82元 ;成本 效果比分别为 2 .36、16 .31、3.38和 16 .2 4。 结论 :头孢唑啉为成本 效果最低 ,但其有效率亦最低 ,舒他西林、氧氟沙星、头孢呋辛三种药物中氧氟沙星的治疗有效率最高 ,成本最低 ,为治疗中老年患者下呼吸道感染的理想药物。

Objective: To compare the therapeutic effects and the costs among Cefazolin, Sultamicillin Ofloxacin,and cefuroxime on peumonia in middle-older patients. Methods: Using pharmacoeconomic cost-effectiveness analysis, 250 cases of penumonia admitted from Janurary 2000 to April 2003 were collected and divided into four groups: Cefazolin was given to group Ⅰ,Sultamicillin was given to groupⅡ, Ofloxacin was given to group Ⅲ, Cefuroxime was given to group Ⅳ. Results: The effective rates of four groups were similar (P>0.05), they were 55.36%,15.22%,73.97% and 69.39% respectively, the costs were 130.59, 1 064, 249.85 and 1 126.82 yuans respectively. The cost-effectiveness ratios were 2.36,16.31,3.38 and 16.24. Conclusion: Among the four schemes, scheme Ⅰ has the lowest cost-effective ratio, and its effective rate was lower also, the effective rates of scheme Ⅱ,Ⅲ and Ⅳ were higher compared with scheme Ⅰ. and the scheme Ⅲ has the lowest expense among scheme Ⅱ, Ⅲ, Ⅳ.