Survivin在泌尿系肿瘤的研究进展

Progressive researchs of survivin in urological cancer

抗凋亡因子survivin是近年来发现的凋亡抑制蛋白。它高表达于胚胎、发育的胎儿组织以及大多数肿瘤组织。目前认为 ,survivin不仅参与细胞分裂 ,同时具有抗凋亡作用。研究发现survivin与泌尿系肿瘤的发生、发展及预后密切相关 ,而且它可作为一个新的靶点对肿瘤进行基因治疗。作者对survivin在泌尿系肿瘤的研究进展作一综述。

The factor of antiapoptosis in cancer is recently identified as survivin. Survivin is prominently overexpressed in embryonic and fetal tissues, and various human cancers. It is potentially involved in both inhibition of apoptosis and control of cell division. Recently, survivin is found to be correlated with the genesis, progress, and prognosis of urological cancer. Manipulation of the antiapoptotic pathway maintained by survivin may be beneficial for cancer therapy. Progressive research of survivin in urological cancer.