血清睾酮与老年男性原发性骨质疏松症的关系

Relationship between primary osteoporosis and serum testosterone in old man

目的 探讨血清睾酮与老年男性原发性骨质疏松的关系,为防治老年男性原发性骨质疏松症提供理论依据。方法 双能X线骨密度仪测定腰椎(L1-4)骨密度;全自动生化分析法测定尿钙、肌酐;AKP用比色法,Ca、Mg用MTB法,P用磷酸亚铁胺法;放射免疫法测定血清E2、T、BGP、CT、PTH-m。获得的参数骨质疏松组与正常对照组比较。结果 男性原发性骨质疏松组骨代谢生化指标与同年龄同性别的对照组比较,血清Ca、P、Mg、Cu以及PTH-m、E2、AKP、BGP两组差异无显著性;血清降钙素显著降低;尿钙与肌酐比值非常明显地增多;男性主导性激素睾酮骨质疏松组非常明显地低于对照组。结论 老年男性原发性骨质疏松的发病因素虽然是多方面的,但血清睾酮水平的降低是老年男性骨质疏松症发病的一个非常重要的原因。

Objective To study the relationship between primary osteoporosis and level of serum testos-terone in old man, and provide evidence to prevent and treat primary osteoporosis for old man. Methods Spinal bone mineral density was measured by dual energy X-ray absorptiometry; urine calcium(Ca) and creatinine were determined with a full-automatic biochemical analyzer, serum AKP by colorimetric method, serum calcium (Ca) and magnesium (Mg) by MTB method, serum phosphorus(P) by ferrous phosphate amine method, serum estradiol (E2), testosterone ( I ), bone Gla protein(BGP), calcitonin(CT), and parathormone-m(PTH-m) by radioim-munoassay. Obtained parameters were compared between osteoporosis group and normal control group. Results There were no significant differences in serum Ca, P, Mg, Cu, PTH-m, E2, AKP, and BGP between the two groups. Serum calcitonin (CT) and testosterone ( I ) decreased significantly (P<0.05,P<0.01), while the ratio of urine calcium to creatinine increased significantly (P < 0.01) in aged osteoporotic male patients, compared with control group.Conclusion Although many factors contribute to primary osteoporosis in aged man,the decrease in serum testosterone is a very important cause.