D-半乳糖对小鼠骨矿物质、羟脯氨酸含量及最大载荷的影响

Influence of D-galactose on content of bone mineral, hydroxyproline and maximum load in mice

目的 研究D-半乳糖致衰老过程中对骨质的影响。方法 用D-半乳糖注射BALB/c断乳雄性小鼠4个月,建立衰老模型,对青年组、模型组和正常老龄组进行股骨长度、重量、最大载荷和功、骨钙、磷、镁、锰、以及骨羟脯氨酸等指标的检测与比较。结果 模型组最大载荷和功、骨钙、镁、锰及羟脯氨酸含量均比青年组有显著降低(P<0.01),而骨磷含量比青年组有显著升高(P<0.01),这些变化与自然衰老组的变化趋势一致,并且自然衰老组改变更为明显。结论 长期大量的使用D-半乳糖可能导致骨质疏松症。

Objective To study the influence of D-galatose on mineral,hydroxyroline and maximum load in aging mice. Methods To cause aging, were mine BALB/c given injctions of D-galactose for 4 months.The bone calcium, phosphorus, nagnesium, manganese, hydroxyproline and femur maximum load and works were defer-mind and compared between mice of young, semile model and natural aging groups. Results Compared with young group, the contents of bone calcium, phosphorous, magnesium, manganese, hydroxyproline and femur maximum load and works in the model group were significamtly decreased (P<0.01orP<0.001) ,the content of bone the natu-ral aging group had. Conclusions D-galactose can cause aging and osteoporosis by producing superoxygen free radical and the advanced glycosylation end products.