绝经后妇女血脂水平与骨密度的关系

Relationship of serum lipid level and bone mineral density in postmenopausal women

目的 明确绝经后妇女血脂水平与骨密度有否联系。方法 测定85例绝经后妇女的甘油三酯和胆固醇水平,双能X线法测定腰椎L2-4和股骨颈的骨密度(BMD)。结果 与未绝经妇女相比,绝经后妇女甘油三酯(t=3.74,P=0.000)和胆固醇(t=3.75,P=0.000)水平均显著升高;而BMD腰椎L2-4(t=2.43,P=0.017)和股骨颈(t=3.32,P=0.002)均显著降低;绝经后妇女甘油三酯水平与股骨颈的BMD经BMI校正后有显著负相关,偏相关系数r=-0.324,P=0.003;而与腰椎L2-4 BMD无相关。胆固醇水平则与股骨颈及腰椎L2-4的BMD均无相关性。结论 绝经后妇女甘油三酯水平的升高可能是绝经后骨量减少及骨质疏松发生的因素之一。

Objective To investigate the relation between serum lipid level and bone mineral density (BMD) in postmenopausal women.Methods Eighty-five screened postmenopausal women were included. The period of menopause was from 1 to 10 years. Lumbar spine and femoral neck BMD were assessed by dual-energy X-ray absorptiometry technique with a Lunar densitometer. Results Both triglyceride (TG) and cholesterin (Chol) level were significantly increased compared to premenopausal women(1.50 ± 0.60 vs 0.92±0.35 for TG, t = 3.74,P = 0.000; 5.77 ±1.01 vs 5.07±0.87forChol,t =3.75,P = 0.000). Nevertheless, both lumbar spine and femural neck BMD were significantly decreased compared to premenopausal women(0.972 ± 0.169 vs 1.056 ± 0.171 for lumbar spine,t = 2.43,P = 0.017 ; 0.829±0.105 vs 0.930±0.177 for femural neck, t = 3.32, P= 0.002). The level of TG was inversely correlated with BMD of femural neck after adjusted for BMI for its known ef-fect on BMD. The partial relation coefficient was - 0.342 at femur neck, The P-value was 0.003. No association was found between the level of Chol and BMD in both lumbar spine and femoral neck. Conclusion The increased TG may be involved in the pathogenesis of postmenopausal osteopenia and osteoporosis.