期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

破骨细胞的局部调节机制

下载PDF
导出
摘要 我国已逐渐进入"老龄化社会",原发性骨质疏松将成为常见多发病.由于骨质疏松常引发骨折等严重的并发症,将使家庭和社会因此承担极大的经济负担.破骨细胞的分化形成与活性对于骨质的正常代谢、再塑形与骨吸收性疾病均起着重要的作用.破骨细胞是由单核/巨嗜细胞系干细胞分化形成的多核巨噬细胞[1-3 ].一些全身性激素类刺激因子对于破骨细胞形成和活性有促进作用,其中包括:1,25二羟基维生素D3[1,25(OH)2D3]、甲状旁腺激素(PTH)、前列腺素E2(PGE2)、白细胞介素-6(IL-6)、IL-11等[4],骨微环境中成骨细胞/骨间质细胞则起着重要的细胞间调节作用,破骨细胞的体外培养证实:对于破骨细胞的分化形成和活性调节,这两者均是必不可缺的.
作者 迟志永 韩纲 王岩
机构地区 解放军总医院骨科
出处 《中国骨质疏松杂志》 CAS CSCD 2004年第2期251-253,共3页 Chinese Journal of Osteoporosis
关键词 破骨细胞 局部调节机制 巨噬细胞集落刺激因子 骨间质细胞 骨保护蛋白 破骨细胞形成抑制因子
分类号 R681 [医药卫生—骨科学]
  • 相关文献

参考文献29

  • 1Lorenz C. Hofbauer, Francesca Gorl, B. Lawrence Riggs, et al. Stimulation of Ostcoprotegerin Ligand and Inhibition of Osteoprotegerin Production by Glucocorticoids in Human Osteoblastic Lineage Cells: Potential Paracrine Mechanisms of Glucocoticoid -Induc
  • 2Akatsu A, Murakami T, Ono K, et al. Osteoclastogenesis Inhibitory Factor Exhibits Hypocalcemic Effects Normal Mice and Hypercalcemic Nude Mice Carrying Tumors Associated With Humoral Hypercalcemia of Malignancy. Bone, 1998, 23: 495-498.
  • 3Brain R. Wong, Jaerang Rho, Joseph Anon, et al. TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells. The Journal of Biological Chemitry,1997, 272: 25190-25194.
  • 4Sun-Kyeong Lee and Joseph Alorenzo. Parathyroid Hormone Stimulates TRANCE and Inhibits Osteoprotegerin Messenger Ribonucleic Acid Expression in Murine Bone Marrow Culture: Correlation with Osteoclast Like Cell Formation. Endocrinology, 1999, 140: 3552-356
  • 5Hisataka Yasuda, Nobuyuki Shima, Nobuki Nakagawa, et al. Osteoclast Differentiation Factor is a Ligand For Osteoprotegerin/OsteoclastgenesisInhibitory Factor And is identical to TRANCE/RANKL. Cell Biology,1998, 95:3597- 3602.
  • 6Kiyoko S. Akagawa, Naomi Takasuka, Yuko Nozaki, et al. Generation of CD1 + RelB + Dendritic Cells and Tartrate-Resistant Acid Phosphatase-Positive Osteoclast-Like Multinucleated Giant Cells From Human Monocytes. Blood, 1996, 88: 4029-4039.
  • 7Wiktor-Jedrmjczak W, Ahmed A,Szczylik C, et al. Hematological characterization of congenital osteopetrosis in op/op mouse. Possible mechanism for abnormal macrophage differentiation. J Exp Med, 1982, 156:1516-1527.
  • 8Olle NA. Vidal, Klara Sjogren, Bengt I. Eriksson, et al. Osteoprotegerin mRNA Is Increase by Interleukin-1α in the Human Osteosarcoma Cell Line MG-63 and in the Human Osteoblast-Like Cells. Biochem-Biophys-Res-Commun, 1998, 248: 696-700.
  • 9Helena Brandstrom, Kenneth B. Jonsson, Olle Vidal, et al. Tumor Necrosis Factor-α and -β Upregulate the Levels of Osteoprptegerin mRNA in Human Osteosarcoma MG-63 Cells. Biochemical And Biophysical Research Communications, 1998, 248: 454-457.
  • 10Nobuaki Nakagawa, Hisataka Yasuda, Kazuki Yano, et al. Basic Fibroblast Growth Factor Inhibits Osteoclast Formation Induced by lα,25-Dihydroxyvitamin D3 through Suppressing the Production of Osteoclast Differentiation Factor. Biochem-Biophys-Res-Commnn,
中国骨质疏松杂志
2004年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部