真皮替代物修复皮肤缺损减少增生性瘢痕的作用

Effect of dermal surrogate in reducing hyperplastic scars by repairing cutaneous deficiency

目的探讨真皮替代物治疗增生性瘢痕的新方法。方法用异种(猪)脱细胞真皮基质作为人真皮层替代物与自体刃厚皮复合移植修复瘢痕切除后的创面。结果16例复合移植后创面一次修复,皮片成活好,瘢痕增生少,弹性好,远期复合皮肤可达全厚或中厚皮移植效果。结论采用脱细胞异种(猪)真皮基质作为正常真皮层的替代物为治疗大片成熟不良,久年不退的瘢痕提供一种新的可行方法,显示用真皮替代物修复缺如的真皮层可以起到控制瘢痕增生的作用。

AIM: To investigate a new method to cure hypertrophic scar with a kind of dermal surrogate.METHODS:Composite transplants of acellular heterologous (porcine) dermis matrix,as a new dermal surrogate,and autologous split thickness skin were grafted to repair heypertrophic scar after scar resection.RESULTS:Sixteen cases of composite transplantations were performed after scars excision. Satisfactory survival rates and clinical results were gained.Composite skins had less scar formation and fine elasticity.Their long term results were analogous with moderate or full thickness skin grafts.CONCLUSION: Acellular heterologous (porcine) dermal matrix can be used as dermal surrogate to cure post burn massive hypertrophic scars of arrest of maturation, which shows that the dermal matrix repaired by dermal surrogate can control hyperplastic scar.