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组织工程软骨研究中各种生长因子的协同作用和最佳效应 被引量：2

Cooperative function and best effect of various growth factors in cartilage study of tissue engineering
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摘要 组织工程技术的核心是将种子细胞接种到三维立体支架上,形成两者的复合体,复合体在体外培育一段时间后,进行体内移植以进行受损组织或器官的修复和替换。近年来的研究发现,生长因子对细胞的生长、增殖以及组织工程化人体组织的构建均有重要作用。这些生长因子可通过传输信号来调节细胞活动。但它们的半衰期很短,可是通过生长因子与生物材料结合则可以延长这些因子的生物活性,并能控制其释放。目前,在合成性的支架材料中复合生物活性因子,已被认为是组织工程可能的应用方法之一。
作者 林建华
机构地区 福建医科大学附属第一医院骨科
出处 《中国临床康复》 CAS CSCD 2004年第23期4808-4809,共2页 Chinese Journal of Clinical Rehabilitation
关键词 生物医学工程 软骨 生长物质
分类号 R318 [医药卫生—生物医学工程]
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参考文献24

  • 1[1]Rosen V,Cox K,Hattersley G.Morphogenetic Porteins.In Belizikian JP,Raisz JG,Rodan GA(eds).Principles of Bone Biology.New York:Academic Press,1996:661-71
  • 2[2]Mont MA,Jones LC,Elias JJ,et al.Struct-autografting with and without osteogenic protein 1:a preliminary study of a canine femoral head defect model.J Bone Joint Surg Am 2001;83-A(7):1013-22
  • 3[3]Suzuki T,Bessho K,Fujimura K,et al.Regeneration of defects in the articular cartilage in rabbit temporomandibular joints by bone morphogenetic protein-2.Br J Oral Maxillofac Surg 2002;40(3):201-6
  • 4[4]Sellers RS,Zhang R,Glasson SS,et al.Repair of articular cartilage defects one year after treatment with recombinant human bone morphogentic protein-2(rhBMP-2).J Bone Joint Surg Am 2000;82(2):151-60
  • 5[5]Mason JM,Breitbart AS,Barcia M,et al.Cartilage and bone regeneration using gene-enhanced tissue engineering.Clin Orthop 2000;(379 Suppl):S171-8
  • 6[6]Gelse K,von der Mark K,Aigner T,et al.Articular cartilage repair by gene therapy using growth factor producing mesenchymal cells.Arithritis Rheum 2003;48(2):430-41
  • 7[7]Sandberg MM,Aro HT,Vuorio EI.Gene expression during bone repair.Clin Orthop 1993;(289):292-312
  • 8[8]Zheng MH,Wood DJ,Wysocki S,et al.Recombinant human bone morphogenetic protein-2 enhances expression of interleukin-6 and transforming growth factor-beta 1 genes in normal human osteoblast-like cells.J Cell Physiol 1994;159(1):76-82
  • 9[9]Pujol JP,Galera P,Redini F,et al.Role of cytokines in osteoarthritis:comparative effects of interleukin 1 and transforming growth factor-beta on cultured rabbit articular chondrocytes.J Rheumatol Suppl 1991;27:76-9
  • 10[10]Zellin G,Beck S,Hardwick R,et al.Opposite effects of recombinant human transforming growth factor-beta 1 on bone regeneration in vivo:effects of exclusion of periosteal cells by microporous membrane.Bone 1998;22(6):613-20

二级参考文献18

  • 1[2]Yang L,Duan XJ.The front problem of seed cell research in bone tissue engineering.Zhonggou Linchuang Kangfu(Chin J Clin Rehabil) 2002;6:532- 3
  • 2[3]Boden SD.Bioactive factors for bone tissue engineering. Clin Orthop 1999;367: 84- 94
  • 3[4]Niyibizi C, Baltzer A, Lattermann C, et al.Potential role for gene therapy in enhancement of fracture healing.Clin Orthop 1998;355:148- 53
  • 4[5]Scaduto AA, Lieberman JR.Gene therapy for osteoinduction.Orthop Clin North Am 1999;30(4):625- 33
  • 5[6]Evans CH, Robbins PD.Possible orthopaedic applications of gene therapy.J Bone Joint Surg Am 1995;77(7):1103- 14
  • 6[7]Shu JC,Zhang CC.Action and principle of gene transfer in racture heal.Xiandai Kangfu(Modern rehabil) 2001;5:62- 3
  • 7[8]Alend TD, Pittman DD, Hankins GR, et al. In vivo endochondral bone formation using a bone morphogenetic protein 2 adeoviral vector.Human Gene Ther 1999;10(13):2245- 53
  • 8[9]Lieberman JR, Daluiski A, Stevenson S, et al.The effect of regional gene therapy with bone morphogenetic protein- 2 producing bone marrow cells on the repair of segmental femoral defects in rats.J Bone Joint Surg Am 1999;81(7):905- 17
  • 9[10]Okubo Y, Bessho K, Fujimura K,et al.Expression of bone morphogenetic protein 2 via adenoviral vecto on C2C12 myolasts induces differentiation into the osteoblast lineage. Biochem Biophys Res Commun 1999;262(3):739- 43
  • 10[11]Gazit D,Turgeman G,Kelley P, et al.Engineered pluripotent mesenchymal cells integrate and differentate in regeneration bone: a novel cell mediated gene therapy.J Gene Med 1999;1(2):121- 33

共引文献32

同被引文献9

引证文献2

二级引证文献7

中国临床康复
2004年 第23期

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