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MAGE家族蛋白质生理功能的研究进展 被引量：1

Progress in the physiological functions of MAGE family.
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摘要 MAGE家族基因编码的肿瘤排斥抗原已经被人们应用于肿瘤免疫治疗 ,最近的研究发现MAGE家族还包含一类特殊的基因在正常组织也有表达 ,且在细胞信号转导 ,细胞凋亡调控以及哺乳动物胚胎发育过程中起明显的传递和协同作用。但是人们对MAGE家族基因及其蛋白质的功能仍然知之甚少。本文对近年来MAGE家族蛋白质生理功能的研究进展作一综述。 Tumor antigens codeb by MAGE family genes have been applied to tumor immunotherapy.Recent research has revealed that a few of genes in this family express in normal tissues and are associated with intracellular signaling transduction pathways,apoptosis regulation and mammal embryo development.Proteins in MAGE family may have other important functions unknown.
作者 隋延仿 曹子鹏
机构地区 第四军医大学病理学教研室肿瘤抗原肽及生物治疗实验室 第四军医大学营养教研室
出处 《现代肿瘤医学》 CAS 2004年第4期273-276,共4页 Journal of Modern Oncology
基金 国家自然科学基金 ( 3 0 2 714 64 ) 全军医药卫生科研基金 ( 0 12 0 84)重点资助项目
关键词 MAGE蛋白 信号转导 细胞凋亡 胚胎发育 mage intracellular signaling pathways apoptosis development
分类号 R730.23 [医药卫生—肿瘤]
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参考文献26

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同被引文献28

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现代肿瘤医学
2004年 第4期

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