倍他乐克对急性心肌梗死患者心率变异性的影响

Effects of betaxolol on heart rate variability of acute myocardial infarction

目的:探讨倍他乐克对急性心肌梗死患者早期的心率变异性的影响。方法:符合该研究入选标准的急性心肌梗死患者48例,其中未使用倍他乐克者19例为对照组,使用倍他乐克1周以上者24例为治疗组,于发病第2周末或第3周行24小时动态心电图检查,比较两组24小时最大心率(HRmax)、最小心率(HRmin)、心脏缺血总负荷(TIB)和HKV各项时域指标。结果:治疗组和对照组间HRV的HR、SDNN、SDANN、PNNS0均有显著性差异(P<0.05或P<0.01)。结论:急性心肌梗死患者早期使用β受体阻滞剂(倍他乐克)不仅能减少心脏缺血的发生而且可升高HRV,改善失衡的自主神经功能。

Objective: To study the effect of betaxolol on HRV (heart rate variability) of acute myocardial infarction (AMI). Methods: A total of 43 cases of AMI were classified as the treatment group (n = 24) with betaxolol and control group (n = 19). HRV analysis by Holter tapes was performed in 43 patients in end of second week or third week after AMI. Results:HRV parameters of the treatment groups were higher than those of the control group. There was very significant difference (P<0. 01) in HRmax, SDNN, SDANN, and there was significant difference (P< 0.05) in the average heart rate, PNN50. Conclusion: Betaxolol can elevate HRV and improve in-balance of the autonomie nervous system in the early stage after AMI.