黄酮化合物的合成新方法

New Synthetic Methods of Flavones

黄酮类化合物具有广泛而重要的生物活性和药理作用 ,其化学合成研究受到普遍重视 .经典的合成方法主要是查耳酮路线和 β 丙二酮路线 .近年来有很多新技术、新方法在黄酮化合物合成中得到了巧妙的应用 .对近年来出现的新的改进的Baker Venkataraman法。

Flavones are a group of naturally occurring compounds that widely distributed in the plant kingdom, and have been associated with a wide variety of biological and pharmaceutical activities. Traditionally there are two main methods available to synthesize flavones, i. e., the chalcone route and Baker-Venkataraman method. Recently, many new methods have been discovered for the synthesis of flavones. The modified Baker-Venkataraman methods and carbonylative annulation of iodophenol acetate, and other new methods for constructing flavones are reviewed in this paper.