新的含大体积取代基的β-氨基醇配体的合成及在二乙基锌对芳香醛的不对称加成反应中的应用

Novel β-Aminoalcohols with Bulky Substitutents and the Application in Enantioselective Addition of Diethyl Zinc to Arylaldehydes

以L 脯氨酸为起始原料 ,两个在其羟基所在的α C上具有大体积取代基的 β 氨基醇配体被简便地合成出来 ,并被用于催化二乙基锌对醛的不对称加成 ,得到了ee值较高的S构型的手性二级醇 .

Two β-aminoalcohols possessing bulky substituents on the carbon atom with the hydroxyl group were readily synthesized from L-proline, and used as chiral ligands for catalytic asymmetric addition of diethyl zinc to arylaldehydes. The resultant second alcohols with S configuration as well as good to higher ee values were achieved. The results showed that much bulkier substituents could not induce higher enantioselectivity.